Since these two cancer genes cooperate to drive experimental lymphomagenesis in mice and have been associated with a particularly poor prognosis when concurrently mutated and translocated, respectively, in adult DLBCL, a deeper mechanistic understanding of the interactions between p53 and MYC in paediatric B-NHL may be particularly informative in this regard [29, 32, 38]. The gene discussed is MYC; the disease is cancer.