EZH2 and glioblastoma: Given that enhancer of zeste homolog 2 (EZH2), the component of polycomb repressive complex 2 (PCR2), is a methyltransferase for the methylation of histone H3 at lysine 2734 and NEAT1 was previously reported to bind to EZH2 to mediate the trimethylation of H3K27 in glioblastoma cells35, we performed an RNA-FISH assay to determine the relationship between NEAT1, SRSF2, and EZH2.