Five of these categories (anthropometric, bone health, cardiovascular, diabetes, and sex hormones) contain traits that relate to or include genetically established endometrial cancer risk factors (e.g. body mass index2, LDL and HDL cholesterol17, insulinemia18, estradiol19, sex hormone-binding globulin (SHBG) and testosterone20). The gene discussed is SHBG; the disease is endometrial cancer.