To prioritise the genes identified by JTI, we performed a Mendelian randomization (MR) causal inference analysis in the respective tissues using MR-JTI, providing five candidate endometrial cancer susceptibility genes: CYP19A1, SNX11, AC021755.3, EEFSEC, and EIF2AK4 (Table 2). The gene discussed is EIF2AK4; the disease is endometrial cancer.