Thus, the two multi-tissue TWAS and associated analyses prioritized eight candidate endometrial cancer susceptibility genes: AC021755.3, EEFSEC, EIF2AK4, CYP19A1, HEY2, SNX11, EVI2A, and SKAP1. Gene expression of the candidate susceptibility genes was generally positively correlated across the solid tissues studied (Fig. 1a–h). This evidence concerns the gene HEY2 and endometrial cancer.