Our data in these NASH-related studies demonstrate that the compound, a GABA-B receptor agonist, has antifibrotic, anti-inflammatory, and hepatoprotective activity in cultured primary and immortalized human stellate cells, in human liver slices, and in a murine model of NASH whose features closely mirror human NASH. The gene discussed is GABBR1; the disease is metabolic dysfunction-associated steatohepatitis.