The sepsis risk score was logit(P) = 2.294*X1 + 2.734*X2 + 2.549*X3-3.714 (X1 = 1, if uCRP/u-Cr > 746.1 μg/mmol; X1 = 0, if uCRP/u-Cr > 746.1 μg/mmol; X2 = 1, if uLRG1/u-Cr > 1174.8 μg/mmol; X2 = 0, if uLRG1/u-Cr < 1174.8 μg/mmol; X3 = 1, if uSAA/u-Cr > 4.4 μg/mmol; X3 = 0, if uSAA/u-Cr < 4.4 μg/mmol). The gene discussed is ISG15; the disease is Sepsis.