COL4A5 and Alport syndrome: In addition, the mutant rats which were integrated the other flame-shift tandem STOP codons (Col4α5 15 aa stop; Supplementary Fig. 2) and were deleted 56 bp including the first ATG (Col4α5 56 bp deletion; Supplementary Fig. 3), also generated, and revealed the same phenotype as Alport syndrome rats (Supplementary Fig. 2, 3).