By contrast, among up-regulated proteins in FSGS there were ANXA13 (Annexin A13), as most significant and promising potential biomarker, to distinguish peritoneal dialysis effluent exosomes of FSGS from No FSGS patients (with 100% accuracy), CENP-E (Centromere-associated protein E) and FNC2 (Ficolin-2). The gene discussed is FCN2; the disease is focal segmental glomerulosclerosis.