Further studies on the biological role of mTORC1/S6K/Akt/PLK1 signaling in the control of cellular TCTP levels will improve our understanding of TCTP function in tumor maintenance and carcinogenesis considering its established roles in malignant transformation8,9, tumor reversion2,10,12,13, anti-apoptotic function13–17, and DNA damage sensing and repair41–43. This evidence concerns the gene RPS6KB1 and neoplasm.