TPT1 and lung carcinoma: To ensure that the high level of TCTP protein in lung cancer cells was mTORC1-dependent, mTOR activity was inhibited using siRNAs targeting Raptor and Rictor, components of the mTORC1 and mTOR complex 2 (mTORC2), respectively, or PP242, an mTOR kinase inhibitor targeting both mTORC1 and mTORC2.