Recently, it has been demonstrated that the TCTP protein promotes the degradation of p53 protein, stabilization of myeloid leukemia cell differentiation protein 1 (Mcl-1) protein, and inhibition of Bax dimerization, all of which promote cell survival7,13–17 and explain how increased expression of TCTP in cancer promotes tumor growth and maintenance. The gene discussed is TP53; the disease is cancer.