As for wave 1, significant differences and increasing trends of IL-1β, IL-1ra, IL-2, IL-6, IL-8, IL-10, GM-CSF, IFN-γ, IP-10, were observed in the three groups (Controls ≤ Mild COVID-19 ≤ Severe COVID-19) (Table 2). The gene discussed is CXCL8; the disease is COVID-19.