Additionally, the presence of horizontal pleiotropy in the MVMR analysis based on heterogeneity tests suggested that PCSK9, LPL, APOC1, APOE, PVRL2, APOB, APOC3, CETP, APOA1, and CELSR2 may affect CHD through additional pathways beyond the lipid sub-fractions LDL-C, HDL-C, and TG included in the current model. This evidence concerns the gene APOC3 and coronary artery disorder.