PVR and early-onset autosomal dominant Alzheimer disease: Besides genome-wide significant associations with diseases of the circulatory system, variants in six drug target genes showed genome-wide significant associations with type 2 diabetes (NDUFA13, CILP2, PVRL2, VEGFA, APOC1, and LPL), five with Alzheimer’s disease (APOC1, PVR, PVRL2, APOE, and CEACAM16), four with asthma (SMARCA4, CETP, VEGFA, and ALDH1A2) and four with gout (APOA1, APOC3, APOA4, and APOA5).