IL6R and early-onset autosomal dominant Alzheimer disease: For example, with the increasingly available data on inflammatory biomarkers, this approach could be used to evaluate the causal role of anti-inflammatory drug targets, such as IL6R, in CHD, Alzheimer’s disease, and major depression, following up on associations described in several studies44–46, to identify potential new indications for anti-inflammatory agents established in the treatment of autoimmune conditions.