Additionally, the presence of horizontal pleiotropy in the MVMR analysis based on heterogeneity tests suggested that PCSK9, LPL, APOC1, APOE, PVRL2, APOB, APOC3, CETP, APOA1, and CELSR2 may affect CHD through additional pathways beyond the lipid sub-fractions LDL-C, HDL-C, and TG included in the current model. Here, APOE is linked to coronary artery disorder.