TNF and glioblastoma: Only one pathway was enriched for in all patients (Hepatic fibrosis, which comprises PDGF/TNF/VEGFR/EGFR/FGF, all molecular cascades known to be deregulated in GBM), three pathways were shared among the majority of patients (Axonal Guidance Signalling, Antigen Presentation Pathway and Glutamate Receptor Signalling) but the majority of pathways were enriched for in individual or few patients (Fig. S5a).