However, stable disease was induced in 50% of patients with refractory metastatic colorectal cancer when EVE was combined with tivozanib (an oral VEGF receptor-1, -2, -3 inhibitor) [28], and a 60% response rate was reported when EVE was combined with the chemotherapeutic agent irinotecan and the anti-EGFR antibody panitumamab [29]. Here, EGFR is linked to metastatic colorectal cancer.