Inhibition of p38 MAPK activity with SB203580 lessened the ability of C75 to upregulate BIM, NOXA, and PUMA (Fig. S1f, g), indicating that ROS-driven activation of stress-induced kinases is linked to the induction of BH3-only proteins in FASN-inhibited cancer cells. This evidence concerns the gene BCL2L11 and cancer.