This is an important piece of information carrying significant clinical relevance for COVID-19 as ACE-2 can be considered as a cell “entry door” for SARS-CoV-2 and because it has been demonstrated that SARS-CoV-2 infection can be intensified due to over-expression [51] and depreciated due to inhibition of ACE-2 [52–54]. This evidence concerns the gene ACE2 and COVID-19.