CRP and septic shock: In the univariate linear regression analyses, TMAO concentrations correlated positively with prior CAD, the CRP level, daily calorie and protein intakes, the BMI, the albumin, prealbumin level, and the NRI; and negatively with the main arterial pressure (MAP), septic shock, number and duration of previous antibiotic treatment courses, eGFR at the time of ICU admission, and NRS-2002 score (showed in Table 2).