Moreover, an MSC large-scale culturing technique (the United States Patent Application Number 13/517,068) generated HF-MSC in large numbers by using microspheres and spinning bottles, providing sufficient quantity for treatment supply.Bone marrow-derived MSC (BMSC) decreases AA incidence by inhibiting IFNG, Chemokine Ligand 1 Protein (CXCL) 9, and CXCL10 production and reducing CD8+NKG2D+ T cell infiltration [46]. Here, IFNG is linked to hydrops fetalis.