Especially, the recent studies have documented that mTOR inhibition by rapamycin reduced myocardial infarct size, which is evidence to evaluate cardiac hypertrophy, with inhibiting cardiomyocyte apoptosis and preserving cardiac function in aortic-banded mice following myocardial ischemia reperfusion (MI/R) [31]. The gene discussed is MTOR; the disease is cardiac hypertrophy.