According to them, functional TAS2Rs coupled with the canonical signalling components, such as β-subunit of gustducin and PLC-β2, were detectable in primary leukemic cells of patients with acute myeloid leukaemia (AML) at diagnosis or in human leukaemia cell lines (OCI-AML3, THP-1) (Table 4). Here, GNAT3 is linked to acute myeloid leukemia.