Colonic villous adenoma-like growth pattern and immunohistochemical profile of MUC2-, MUC5AC- and CDX2-positivities but MUC1- and MUC6-negativities in the present case indicated that the lesion was consistent with the intestinal type IPMN. The gene discussed is MUC5AC; the disease is pancreatic intraductal papillary-mucinous neoplasm.