PODXL and focal segmental glomerulosclerosis: At urinary pole, PECs express CD133 and CD24 without podocyte markers (nestin, complement receptor-1, and podocalyxin), which were defined as CD133+CD24+PDX− PECs; In the same way, they were defined as CD133−CD24−PDX+ PECs in the vascular pole and CD133+CD24+PDX+ PECs in the rest of regions [8]; In the case of progressive podocyte depletion, PECs begin to express podocyte proteins, including those related to focal segmental glomerular sclerosis (FSGS), aging nephropathy, and membranous nephropathy [13, 14].