We also observed an overall negative association between NME4 and tumor invasion markers in this tumor type, in particular between NME4 and MMP14, the key player of invasion, and between NME4 and markers of invadopodia, the plasma membrane protrusions responsible of matrix degradation and enriched in MMP14 (Additional file 25: Table S5). The gene discussed is MMP14; the disease is neoplasm.