TUBB2A and cancer: This includes up-regulation of two proteins closely linked to metastasis, actin-bundling fascin (FSCN1) [40] and S100 protein family member S100A4 (S10A4) [41, 42], further tubulin beta-2A (TBB2A), involved in cancer progression together with other tubulin isotypes [43], and finally γ-synuclein (SYUG), a protein with unknown function but predicting bad prognosis in various cancers [44] and promoting invasion and metastasis in in vitro assays as well as in animal models [45].