In multivariable analyses (Table 4), decompensated liver (adjusted OR 2.78; 95% CI 2.44–3.17), age > 65 years (adjusted OR 2.35; 95% CI 2.05–2.70), male gender (adjusted OR 2.24; 95% CI 1.98–2.53), elevated ALT (adjusted OR 1.97; 95% CI 1.74–2.24), Hispanic ethnicity (adjusted OR 1.66; 95% CI 1.39–1.99), diagnosed with diabetes (adjusted OR 1.27; 95% CI 1.10–1.46), and a smoking history (adjusted OR 1.20; 95% CI 1.05–1.38) were associated with HCC. The gene discussed is GPT; the disease is hepatocellular carcinoma.