This leads to the hypothesis that DG show a higher response to medical treatment with somatostatin analogs such as octreotide, which have a high affinity to SSTR2, as supported by the analysis of Ezzat et al. In their study, DG adenomas showed a higher decrease in GH levels by inhibition of GH secretion during pharmacotherapy with octreotide than did SG adenomas [50]. This evidence concerns the gene GH1 and adenoma.