In a model of chronic inflammatory disorder, as rheumatoid arthritis, the antagonism of TNF-α with infliximab reduced the infarct volume and the amount of microglia and activated macrophages in the ischemic hemisphere and improved the integrity of BBB and the neurological deficit in mice with ischemia/reperfusion (I/R) brain injury [136]. This evidence concerns the gene TNF and rheumatoid arthritis.