PECAM1 and myocardial infarction: In mice with permanent LAD artery ligation, cardiac EVs were transiently accumulated in the infarcted heart, with a peak between 15 and 24 h post-MI, and originated mainly from cardiomyocyte (caveolin-3+; Troponin T+), cardiac fibroblast (CD90.2+), and endothelial cells (CD31+CD41−), while only a small population of leukocyte-derived CD45+ EVs was detected.