In details, these EVs have in common 14 proteins which were absent in healthy controls, such as apolipoprotein L1 (APOL1) and apolipoprotein C (APOC); involved in lipid metabolism; and complement C4 (C4) and C-reactive protein (CRP), factors, and activators of the complement system, which is activated after stroke and MI and contributes to tissue injury after ischemia. This evidence concerns the gene APOL1 and Stroke.