In details, these EVs have in common 14 proteins which were absent in healthy controls, such as apolipoprotein L1 (APOL1) and apolipoprotein C (APOC); involved in lipid metabolism; and complement C4 (C4) and C-reactive protein (CRP), factors, and activators of the complement system, which is activated after stroke and MI and contributes to tissue injury after ischemia. The gene discussed is CRP; the disease is Stroke.