In rat with MI, the upregulation of miR-1 expression partially contributed to the post-transcriptional repression of hyperpolarization-activated cyclic nucleotide-gated channel (HNC) protein expression, which may contribute to the effect of spironolactone to reduce the incidence of MI-associated ventricular arrhythmias [159]. Here, MMP8 is linked to myocardial infarction.