However, the cerebral expression levels of miR-499-5p were gradually decreased after perinatal hypoxic-ischemic encephalopathy (HIE) in rats, while miR-499-5p injection significantly improved long-term neurological function recovery and decreased HIE-induced brain injury, reducing apoptotic neurons in the hippocampus, the infarct size, and level of CRP [98]. The gene discussed is CRP; the disease is perinatal asphyxia.