AKT1 and Parkinson disease: In cell culture models of Parkinson’s disease, the overexpression of miR-133b ameliorated the MPP+-induced axon degeneration, blocking the MPP+-induced decrease in the Bcl-2/Bax ratio and increasing the activity of the pro-survival kinase Akt (p-Akt) [92], and was involved in the downregulating of α-synuclein [93].