According to the reported epitopes of COVID-19 nAbs, there exist three types of SARS-CoV-2 S protein binding modes: (1) direct binding to the RBM, (2) binding to the RBD outside the RBM [14,15,31,46,47], and (3) binding to the S protein outside the RBD while still exhibiting neutralizing activity [14,46]. The gene discussed is PROS1; the disease is COVID-19.