SOX2 and neoplasm: Concerning tumor subgroup affiliation, hyperactivation of mTORC1 via RhebQ64L in classic HH CSCs resulted in the significant downregulation of WNT pathway–specific markers such as β-catenin (Figure 5D and Supplemental Figure 4C) with concurrent upregulation of p53 mutant SHH subgroup–specific markers, such as Yap1, N-Myc, Gli2, and Sox2 (Figure 5D and Supplemental Figure 4C).