Accordingly, in vivo implantation of naive DAOY cells gave rise to MB that did not show mTORC1 activation in tumor cells and were endowed with desmoplastic/classic histology, implying that p53 mutations should be present in the original tumor to be able to influence the molecular make-up of the tumor (Figure 8D and Supplemental Table 1). Here, TP53 is linked to neoplasm.