PTCH1 and laryngotracheoesophageal cleft: Although the majority of SHH MB with mutant TP53 show amplification of MYCN and/or GLI2 (14), there are reports of rare SHH-TP53mut MB, which are classified as LC/A SHHα and are characterized by concurrent mutations in PTCH1 and TP53 (11, 15).