Detection of reduced Glp1r expression in the livers of Glp1rTie2–/– mice (Figure 1C) prompted us to assess whether hepatic indices of metabolism or inflammation were differentially regulated in atherosclerosis-prone, PCSK9-AAV–treated, HFHC diet–fed mice treated with or without semaglutide. Here, PCSK9 is linked to atherosclerosis.