Here we used a dose of 10 μg/kg/d of semaglutide, demonstrating that reduction of aortic atherosclerosis does not require a functional GLP-1R within ECs or HL cells using the PCSK9-AAV+HFHC diet model of atherosclerosis, which closely mimics the phenotypes exhibited by Ldlr–/– mice (38). The gene discussed is PCSK9; the disease is atherosclerosis.