Here, by using mouse chimeric r84 (mcr84) that specifically inhibits the mouse VEGF/VEGFR2 axis and a genetic mouse model with VEGFR2-specific ablation on myeloid cells, we investigate the function of VEGFR2+ myeloid cells in modulating tumor immunity and provide a comprehensive investigation of how VEGFR2 blockade facilitates an antitumor immune response. Here, KDR is linked to neoplasm.