Consistent with the in vitro cell cytotoxicity assay, histological analysis of in vivo 4T1 and MC38 tumors demonstrated that mcr84-treated tumors showed elevated cleaved caspase-3 (CC3) in the 4T1 model, indicating increased tumor cell death and decreased Ki67 expression in the 4T1 and MC38 models (Supplemental Figure 7, I and J). This evidence concerns the gene MKI67 and neoplasm.