Based on the correlation with AD, the number of different proteins involved in the pathway, and the significant changes in protein expression, we speculate that Erzhi pills can regulate the PI3K/Akt signalling pathway by upregulating 14-3-3 protein expression, subsequently decreasing phosphorylation of tau and inducing neuronal apoptosis and ultimately relieving the pathological symptoms of AD. This evidence concerns the gene MAPT and Alzheimer disease.