If BMD is normal and HRT has been prescribed, the value of a repeat DEXA scan is low.43 Women with known osteoporosis, a strong family history, or those at increased risk due to the use of aromatase inhibitors for breast cancer should have initial and periodic (every 2–5 years) DEXA scans.65 It is not necessary to routinely monitor endometrial thickness while using topical or systemic HRT. This evidence concerns the gene CYP19A1 and breast carcinoma.