INS and diabetes mellitus: It is known that blood urate level is lower in women than in men.25 One possible explanation for the inverse association between blood urate and glycemic status in men is an increasing action of insulin on renal tubular reabsorption of urate26,27: in patients with diabetes, urinary excretion of urate is increased by less tubular reabsorption of urate due to insulin deficiency, resulting in lower blood urate levels.