These neurotoxins induce pro-inflammatory signaling intermediates such as reactive oxygen species (ROS) which in turn up-regulate a series of pro-inflammatory transcription factors such as NF-kB and NF-kB-sensitive transcription to up-regulate pro-inflammatory microRNAs that include miRNA-146a within AD brain and in transgenic AD (TgAD) murine models [12,32,33]. Here, NFKB1 is linked to Alzheimer disease.