For the comparison of cs-PCa with low-risk PCa and non-PCa lesions in TZ patients with PSA 4-20 ng/mL, the differences in the age, t-PSA, f/t-PSA, PSAD, PV, and PI-RADS v2.1 score were statistically significant (P < 0.05), while the f-PSA was not significantly different (P = 0.898). This evidence concerns the gene KLK3 and posterior cortical atrophy.