The cs-PCa detection rate in TZ patients with PSA 4-20 ng/mL was 2.3% (4/173) for PSAD < 0.15 ng/mL/mL, 9.8% (12/122) for PSAD 0.15-0.29 ng/mL/mL, and 44.7% (17/38) for PSAD ≥ 0.30 ng/mL/mL, respectively. This evidence concerns the gene KLK3 and posterior cortical atrophy.