KLK3 and posterior cortical atrophy: As shown in the ROC curve and DeLong's test (Figure 5), the combination of the PI-RADS v2.1 score and PSAD had the highest AUC for TZ cs-PCa in patients with PSA levels of 4-20 ng/mL (AUC = 0.910 (0.874-0.939)), which was significantly larger than that in the PI-RADS v2.1 score (AUC = 0.889 (0.850-0.920), P = 0.039) or PSAD (AUC = 0.803 (0.756-0.844), P < 0.001).