Inflammatory cytokines such as TNF-α and IL-6, highly abundant in obesity and T2D, bind to receptors on the cardiomyocyte surface which triggers downstream activation of NF-κB and other central regulators of cell metabolism with differential impact on cardiomyocyte function (7–9, 86, 136–138). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.