Multiple miRNAs, including miR-515-5p in NSCLC, miR-101, and miR-493 in bladder cancer, and miR-505 in cervical carcinoma, decrease Fzd4 expression accompanied by tumor-suppressive effects (Ueno et al., 2012; Pardo et al., 2016; Ma C et al., 2017; Chen et al., 2019). Here, FZD4 is linked to neoplasm.