Therefore, we can guess the following steps: C1, which is attributed to most low-risk patients, increases the level of lipid oxidation metabolism and induces ferroptosis; ferroptosis heats up the tumor immune microenvironment, activates immune-related pathways, wakes up immune cells, transforms “cold tumor” into “hot tumor,” upregulates the expression of PD-L1, enhancing the sensitivity of immunotherapy; the phenomenon of immune mobilization in turn promotes ferroptosis, forming a positive cycle. Here, CD274 is linked to neoplasm.