Glutathione peroxidase 4 (GPX4) can be used by BC to gain the ability to endure drug resistance, conversely, the loss of GPX4 function can reverse the formation of BC drug resistance, which leads to the persistent ferroptosis process of cells and prevents tumor recurrence, suggesting that targeting GPX4 is a therapeutic strategy for acquired drug resistance (13). The gene discussed is GPX4; the disease is breast cancer.