Hammerich et al. (2019) reported that in situ vaccination can successfully treat indolent non-Hodgkin’s lymphoma. This kind of vaccine contains a TLR3 agonist along with a tyrosine kinase 3 ligand and is combined with radiotherapy. As a result, an anti-tumor CD8+ T-cell response is generated. Even in non-responsive patients, a population of PD1+CD8+ T cells is formed. In this context, untreated distant tumors become sensitive to PD1 treatment; the addition of PD1 treatment increases the therapeutic efficacy from 40% to 80% (Hammerich et al., 2019). This evidence concerns the gene CD8A and non-Hodgkin lymphoma.