Except for a single study which demonstrated down-regulation of SNHG16 in HCC samples versus nearby non-malignant hepatic tissues (Xu et al., 2018), other studies have indicated up-regulation of SNHG16 in malignant tissues of different origins compared with non-neoplastic samples (Supplementary Table 1). The gene discussed is SNHG16; the disease is hepatocellular carcinoma.