RAC1 and Alzheimer disease: The effect of Rac1 in AD is likely mediated by changes in the actin cytoskeleton as Rac1 activation induced by Aβ peptides was associated with increased colocalization with actin filaments in hippocampal neurons, and the inhibition of Rac1 abolished the increased actin filaments (Mendoza-Naranjo et al., 2007).