The SFTPA1 and SFTPA2 have the maximum number of interactions and, along with SFTPD, interacted with SFTPB. All three SNP interactions, except for one intragenic interaction of SFTPB (rs2077079-SNP1, rs3024798-SNP2, rs7316-SNP3 as d1d2d3), involved either SFTPA1 or SFTPA2. This highlights the impact and importance of SFTPA1 and SFTPA2 in RDS. Here, SFTPB is linked to newborn respiratory distress syndrome.