Among the two SNP interactions, the only intragenic interaction included SFTPA1 SNPs; rs1136450 and rs4253527 (Table 3), and this combination exhibited two effects, where the d1d2 interaction was associated with increased risk for RDS (OR 1.77, 96% CI 1.42–2.19, adjusted P = 0.0001), and the d1a2 was associated with protection for RDS (OR 0.54, 95% CI 0.41–0.72, adjusted P = 0.004) (Figure 1). This evidence concerns the gene SFTPA1 and newborn respiratory distress syndrome.