Meanwhile, knockdown of ARID1A in neuroblastoma SK-N-SH cells is found to raise the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) and lessens the expression of E-cadherin, which ultimately leads to the enhancement of neuroblastoma invasion and migration (98), and the upregulated levels of MMP-9 upon ARID1A inhibition is recently shown to be due to the strengthened MMP-9 protein stability in JEG-3 choriocarcinoma cell line (75). The gene discussed is CDH1; the disease is neuroblastoma.