MYC and hepatocellular carcinoma: Given that ARID1A mutations often co-exist with MYC amplification in human HCC, a liver-specific tet-off mouse cancer model based on MYC overexpression and Arid1a knockout (LAP-tTA;TRE-MYC;Arid1a−/−) exhibits rapid preformed tumor growth, suggesting Arid1a deletion accelerated tumor once tumors had formed (30).