On the other hand, upon loss of ARID1A in Kirsten rat sarcoma viral oncogene homologue (KRAS)-mutated cells, enhancers that are co-occupied by ARID1A and AP1 transcription factors become inactive, thereby leading to decreased target gene expression in colorectal cancer cells, which expands the knowledge about the context-dependent functions of ARID1A in colon cancer, particularly in KRAS-mutated cancer cells (55). Here, KRAS is linked to cancer.