In addition to the known GC driver genes including TP53, PTEN, and CTNNB1 as well as genes reported in Catalogue of Somatic Mutations in Cancer (COSMIC) to be mutated in GC, such as TTK and ACVR2A, ARID1A is identified to be a new driver gene for GC development (49). This evidence concerns the gene ARID1A and gastric cancer.