Mechanically, cancer cells lacking ARID1A expression have higher phosphorylation levels of AKT-Thr308 and AKT-Ser473, which is contrary to those in ARID1A-knockdown OCCC cell lines, indicating that phosphorylation of AKT in tumor tissues is regulated by ARID1A indirectly (46). The gene discussed is ARID1A; the disease is neoplasm.