Another study showed that deficiency of Arid1a affects angiopoietin‐2 (Ang2)-dependent angiogenesis, that is, Arid1a loss increases Ang2 expression because of augmented histone H3K27ac modification at the Ang2 gene locus, whose upregulation confers a non-cell-autonomous growth advantage to the malignant HCC (34). This evidence concerns the gene ARID1A and hepatocellular carcinoma.