On patient-based level, network meta-analysis reveals that for numerous tracers, 68Ga-PSMA PET/CT has the highest superiority index, followed by 18F-NaF, 11C-choline, 18F-choline, 18F-FDG, and 18F-fluciclovine PET/CT; for the parameters of MRI, higher magnetic field strength, multisequence, more imaging planes, and MRI with DWI will increase the diagnostic value for bone metastasis in prostate cancer patients. Here, FOLH1 is linked to bone metastasis.