Therefore, to probe the possible clinical and predictive significance of FZD10 delivered by plasma exosomes in the diagnosis and prognosis of CRC and GC, the present study investigated, for the first time, the relationship between the expression levels of the FDZ10 in plasma-derived exosomes and of Ki-67 in tissues from the colon or stomach of CRC and GC patients (at different TNM stages). This evidence concerns the gene MKI67 and colorectal carcinoma.