On the basis of all these above-described experimental evidence that highlighted an active involvement of FZD10-delivering exosomes in carcinogenesis and evolution of CRC and other cancers of the gastroenteric tract, the present clinical study reports follow-up on our previous studies concerning the FZD10 upregulation in the exosomes isolated from the plasma of CRC and GC patients (21). Here, FZD10 is linked to colorectal carcinoma.