(10) proved that ERK-1/ERK-2 phosphorylation was associated with increased Ki-67, thus suggesting that the ERK-1/ERK-2 pathway is active in salivary gland mucoepidermoid carcinoma, and this activation is associated with a more aggressive tumor behavior and a higher proliferative activity. The gene discussed is MAPK3; the disease is salivary gland mucoepidermoid carcinoma.