If membranes and cytoplasm of cells in the tissues of oncological patients, at TNM stages higher than T1, are FZD10 enriched (Figures 1B and 2B), consequently, the corresponding secreted exosomes will be characterized by higher expression levels of FZD10 than that in exosomes from healthy subjects and CRC and GC patients at stage T1 (20). The gene discussed is FZD10; the disease is colorectal carcinoma.