In addition to the subsets of normal B cells (B cell-1 overexpressed CD79A and CD79B), B cell-2 showed an important role in antigen processing and regulating the cytotoxicity of T cells, and its function was similar to that of dendritic cells, which may be related to the abnormal differentiation of B cells in PCNSL. This evidence concerns the gene CD79B and primary central nervous system lymphoma.