Significant compromise (> 2 compromising factors) OR one of the following:     - Absolute neutrophil count <1000     - CD4 t cell count < 100     - Intravenous drug abuse     - Chronic active infection at other site     - Dysplasia/neoplasm of immune system (e.g. Myelodysplasia, CLL). The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.