Several factors may be responsible for the excess TOD associated with hypertension amongst people of African ancestry, including but not limited to differences in salt sensitivity (associated with increased water retention and sodium excretion) [11, 12], genetic factors like apolipoprotein A1 (APOL1) polymorphisms [13, 14], and circulating cytokines, e.g., transforming growth factor beta (TGF-β) [15] and socioeconomic factors [16]. This evidence concerns the gene APOL1 and hypertensive disorder.