NLRP3 and liver dysplastic nodule: Guo Xiaoyuan [52] found that Zi Shen Wan (ZSW: composed of Phellodendron amurense, Anemarrhena, and cinnamon) can reduce the pyroptosis of renal tubular epithelial cells in db/db mice by inhibiting the activation of NLRP3 inflammasomes and can effectively inhibit the mesenchymal changes, and the migration ability of HK-2 cells induced by high glucose can reduce nuclear damage and cell membrane damage, inhibit the expression of pyroptosis-related inflammatory factors, and reduce early renal damage in DN.