PRKG1 and hypertensive disorder: The GWAS conducted by Lorena Citterio on Caucasians with mild hypertension found that SNPs located in the cGMP-dependent protein kinase 1 (PRKG1) gene are associated with changes in the diastolic BP (DBP), whereas SLC24A3 and SLC8A1 are associated with changes in the systolic BP (SBP), which focuses on acute salt loading but that study is limited by modest sample sizes (n = 329), and the results may not apply to other racial groups (Citterio et al., 2011).