The confirmation of Th17 cell infiltration in the glioma tissues gives rise to the investigation of the role of IL-17, one of the major mediators and hallmarks of the Th17 cells, which promotes glioma proliferation and migration through the activation of PI3K/Akt1/NF-κB-p65 axis (120). The gene discussed is NFKB1; the disease is central nervous system cancer.