Since TAMs dominates the infiltrating immunocytes and autophagy is highly involved in M2-like macrophage, a piece of evidence illustrates that the glioma-derived exosomes mainly containing IL-6 and miR-155-3p initiate autophagic activities in TAMs and promote M2-like polarization via IL-6-pSTAT3-miR-155-3p-autophagy-pSTAT3 positive feedback loop (221, 222). This evidence concerns the gene IL6 and central nervous system cancer.