Glioma-derived IL-8 recruits neutrophils to infiltrate, while the recruited ones produce a magnitude of neutrophil extracellular traps (NETs) stimulating the NF-κB signaling pathway in GBM cells and promote IL-8 secretion via HMGB1 binding to the receptor for advanced glycation end products (RAGE) (87). The gene discussed is CXCL8; the disease is central nervous system cancer.