EGFR and central nervous system cancer: Although microRNAs are mostly regarded as biomarkers for diagnosis or prognosis, the synergistic effect of miR-450a-5p overexpression combined with epidermal growth factor receptor (EGFR) inhibitor gefitinib confers the sensitivity to chemotherapy in glioma through the EGFR-stimulated PI3K/AKT/mTOR signaling pathway and further pro-death autophagy activation (245).