Interestingly, disrupting the CD47-SIRPα axis (“don’t eat me” signal) with specific fusion protein binding augments phagocytosis of macrophages, triggers cytoprotective autophagic flux in glioma cells, and further improves not only macrophage but also CD8+ T cell infiltration if combined with autophagy inhibitors (186, 187). The gene discussed is CD8A; the disease is central nervous system cancer.