The bone-marrow-derived macrophages (BMDMs) appear to be defined as CD11b+- CD45+ CD49d+ macrophage population and recruited from peripheral circulating monocytes by glioma, whereas the tissue-resident CD11b+ CD45- CD49d- microglia (MG) are derived from erythro-myeloid progenitors (EMPs) in embryonic yolk sac without postnatal replenishment from peripheral mononuclear hematopoiesis (5, 8, 27). Here, ITGA4 is linked to central nervous system cancer.