Interleukin 1β (IL-1β) released by TAMs reprograms cellular metabolism by boosting glycolysis of glioma through the IL-1β-protein kinase-delta (PKCδ)-glycolytic enzyme glycerol-3-phosphate dehydrogenase (GPD2) axis, which promotes tumor proliferation and tumorigenesis (56). The gene discussed is IL1B; the disease is glioma.