Production of large amount of cytokines (hypercytokemia/hyperchemokinemia), B cell signalling, pathogen recognition receptors (PRRs) recognition of viruses, activation of interferon regulatory factors (IRF) by cytosolic PRRs (MDA-5, RIG-I and LGP2) and the role of protein kinase R (PKR) in interferon induction were found to be upregulated in all infection groups at 72 hpi. Here, DHX58 is linked to infection.